Pre-implantation Genetic Testing (PGT)

08/02/2022

Pre-implantation genetic testing (PGT) is a technique used to identify genetic disorders or abnormalities in the chromosomes of embryos produced by IVF. From there, experts can screen the best embryos to transfer to the mother’s uterus to increase the likelihood of success; reduce the rate of miscarriage, birth defects or genetic diseases.

Consists of:

  • PGT-A to detect abnormalities related to number of chromosomes
  • PGT-SR to detect abnormalities related to chromosomal structure
  • PGT-M to detect disease-specific genetic abnormalities

What cases need to be done?

  • Wife’s age (>35 years old)
  • Repeated miscarriage (≥2 times)
  • IVF failed multiple times (≥ 3 times)
  • History of having a baby with a birth defect
  • Family with genetic diseases, carrying disease genes: Thalassemia, Muscular Atrophy, Hemophilia, Duchenne/Becker muscular dystrophy, etc.
  • Infertility due to severe sperm abnormalities
  • Husband and wife have chromosomal abnormalities

Implementation process:

  • IVF to create embryos, raise embryos to blastocyst stage (Days 5, 6)
  • Embryo biopsies take cells for genetic testing and freeze embryos
  • When the results are available, the doctor will advise on the quality and ability to use the stored embryos
  • Transfer the frozen embryo

According to statistics from June 2021 to June 2022, AF Hanoi has performed 47 Pre-implantation genetic testing cases in which:

  • 8 cases of thalassemia screening
  • 01 case of hemophilia screening
  • 30 consecutive miscarriages
  • 08 cases of elderly women giving birth

IVF success rates with preimplantation genetic screening from 6/2021 to 6/2022:

Positive pregnancy test rate Clinical pregnancy Progressing pregnancy
65.2% 59% 53.8%
Key word: PGT
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