Pre-implantation genetic testing (PGT) is a technique used to identify genetic disorders or abnormalities in the chromosomes of embryos produced by IVF. From there, experts can screen the best embryos to transfer to the mother’s uterus to increase the likelihood of success; reduce the rate of miscarriage, birth defects or genetic diseases.

Consists of:

• PGT-A to detect abnormalities related to number of chromosomes
• PGT-SR to detect abnormalities related to chromosomal structure
• PGT-M to detect disease-specific genetic abnormalities

What cases need to be done?

• Wife’s age (>35 years old)
• Repeated miscarriage (≥2 times)
• IVF failed multiple times (≥ 3 times)
• History of having a baby with a birth defect
• Family with genetic diseases, carrying disease genes: Thalassemia, Muscular Atrophy, Hemophilia, Duchenne/Becker muscular dystrophy, etc.
• Infertility due to severe sperm abnormalities
• Husband and wife have chromosomal abnormalities

Implementation process:

• IVF to create embryos, raise embryos to blastocyst stage (Days 5, 6)
• Embryo biopsies take cells for genetic testing and freeze embryos
• When the results are available, the doctor will advise on the quality and ability to use the stored embryos
• Transfer the frozen embryo

According to statistics in the first 6 months of 2023, Andrology and Fertility Hospital of Hanoi has carried out 143 Pre-implantation Genetic Screening, including:

• 39 cases are elderly women giving birth
• 104 have monogenic disease.

Clinical pregnancy rate on IVF patients screened for the first 6 months of 2023: 58.1%