Pre-Marriage tests assess the risk of children affected Thalassemia

21/11/2024

CÁc XÉt NghiỆm TiỀn HÔn NhÂn ĐÁnh GiÁ Nguy CƠ Con MẮc BỆnh Thalassemia 01

Thalassemia is a hereditary hemolytic disease that causes serious health complications and affects the future of the next generation. With its genetic inheritance through recessive genes from both parents, this condition not only directly impacts the affected individual but also poses a threat to the quality of life and reproductive health of future generations. Therefore, pre-marriage testing to assess the risk of passing on Thalassemia is essential, especially for couples who plan to have children.

The Importance of Pre-Marriage Testing
Pre-marriage testing helps couples determine whether they carry the Thalassemia mutation. Through this screening process, doctors provide accurate analysis and in-depth counseling, helping couples prepare for their reproductive plans and reduce the risk of having a child with the disease.

Diagnostic and Screening Tests for Thalassemia:

  • Complete Blood Count (CBC): This is the basic step to detect abnormalities in blood cell components, helping identify early signs of Thalassemia.
  • Hemoglobin Electrophoresis: This method identifies different types of hemoglobin in the blood, distinguishing between disease types or the risk of carrying the Thalassemia mutation. This is a critical step in assessing genetic risks from parents to children.
  • Biochemical Tests: These tests assess iron levels, ferritin, and bilirubin to detect signs of hemolysis and iron overload, which are common indicators of Thalassemia. Additionally, these tests help differentiate between anemia caused by iron deficiency and other causes.
  • Genetic Testing: This is the most advanced method today, accurately detecting mutations in the alpha and beta globin genes using gene sequencing or PCR techniques with specific primers.

Pre-marriage tests not only help accurately determine the risk of carrying the Thalassemia mutation but also provide peace of mind to couples regarding their reproductive health and the future of their children.


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